Washington, D.C. David Firestone, US Food & Drug Administration, 1978. Unpublished. 4to. 200 pp., on ruled paper, written in manuscript in pen & pencil, numerous charts tipped-in, some w/ multi-coloured graphs & ink, highlights circled in red. Mustard-coloured cloth, black lettering stamped on front cover (some rubbing, edgewear, dustsoiling), w/ tipped-in note on rear pastedown indicating all such notebooks would be recalled by the FDA library for microfilming, and after review would be returned and canceled to the user, as here. Very good. Item #3506
Highly interesting manuscript laboratory notebook, documenting critical research in the effects of elevated levels of Pentachlorophenol (PCP) in milk producing cows, and dairy products.
This significant FDA study on the effects of PCP upon lactating cows was carried out from 1977-1978, against the backdrop of a number of similar studies undertaken across the country examining the effects of PCP upon agriculture due to its heavy use as a common wood preservative. Treated wood used in dairy buildings, facilities, pens, and even as fence posts was proving to infect nearby cattle, and cattle feed, leaving a chemical residue. Increased PCP levels resulted in decreased milk production, higher levels of mastitis, lameness, respiratory difficulties, retained placentas, spontaneous abortions, liver and kidney damage, as well as increased dangers in end-use food supply. This extensive study examined fat content of milk samples, PCP components supplied from labs at Monsanto, spikes of control milk samples, dioxin levels in milk & milk fat, levels in clover, and more.
Dr. Firestone (1923-2017) was an authority on the subject and published widely on it; he later issued with his colleagues the “Chemistry of PCBs and PBBs” in Environmental Health Perspectives, Vol. 24, 1978. Firestone is perhaps best remembered as one of the primary FDA researchers which helped to analyze toxic compounds in fats and oils, such as the dioxins in tallow-derived fatty acids in chicken feeds which caused chick edema in broilers, and killed millions of chickens in the late 1950’s before uncovering the root cause.